Thursday, October 6, 2011

2 important points about treating ACS

I wanted to quickly review 2 issues that come up with regularity when a resident & I have a patient with ACS, either a STEMI or NSTEMI. Let me start with the conclusion first, and go from there.

1. Tachycardia is a reason not to give IV beta-blockers in the ED for NSTEMI or STEMI.
2. Heparin hasn't actually been shown to have much effect in NSTEMI.

Okay, first about the beta-blockers. There used to be a lot more enthusiasm for using IV metoprolol in the ED with a STEMI, and many clinicians still feel that they are obligated to give them. But a lot of that changed, first when the COMMIT trial came out, and then when the AHA modified their guidelines to reflect the new evidence. In that big trial, patients with a STEMI were given the IV metoprolol load in the ED, followed by PO. The kicker is that there was overall no difference in 28 day mortality, since for every person who apparently didn't have a reinfarct or fatal arrhythmia. there was an extra person who died of HF!

Make special note of the risk factors listed after the asterix, in small print, at the bottom: sinus tachycardia exceeding 110 bpm.

These considerations were extended to the NSTEMI guidelines as well, although the evidence base is not as direct or contemporary as it is for STEMI. The 2007 AHA UA/NSTEMI guidelines basically mirror those for STEMI with regard to PO beta-blockers (Class 1 in the first 24 hours) and IV beta-blockers (class 2a, with same contraindications as above).


As for heparin for NSTEMI, it is sort of absurd looking at the recommendations and the supporting evidence. The 2007 AHA UA/NSTEMI guidelines cite 2 studies in support of the use of UFH. The more recent, and larger, was  this paper , a meta-analysis of 6 studies that looked at the benefit of adding heparin to aspirin in UA/NSTEMI.
 Ok, look at the title. Seems like a pretty clear title - you know just what they found in their study, and you should expect to find at least statistical significance in the results, right?
Not really
Right there, first page - the RR for MI or death was not significantly reduced when heparin was added to aspirin. They include this helpful graph, which shows the results of 6 trials, and the summary estimate that they calculate.
In the last few sentences, the authors, note that "this meta-analysis of 6 randomized controlled trials demonstrated a strong trend toward reduction in risk of MI or death during randomized therapy in patients with unstable angina treated with aspirin plus heparin compared with those treated with aspirin alone." The phrase "strong trend" is not found in the conclusion of the abstract, but instead they highlight the "33% reduction" in outcomes. 

 Heparin probably has utility in the sicker subset of NSTEMI, the patients with positive enzymes, dynamic ECG changes, ongoing pain. But those are the kind of patients you're talking about with the cardiologist, calling CCU, and perhaps arranging same-day cath lab evaluation. But for the run o' the mill ACS patient, check out the evidence first.

28 comments:

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  8. Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR Ohunyom helped someone in curing his HERPES disease, quickly I copied his email which is
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    ReplyDelete
  18. I was diagnosed of herpes virus, I have tried all possible means to get cure but all my effort proved abortive, until a friend of mine introduced me to a herbal doctor called Dr Agaba, who prepare herbal medicine to cure all kind of diseases including herpes virus (Herpes), when i contacted this herbal doctor via email, he sent me herpes virus herbal medicine via courier service, when i received the herbal medicine he gave me step by step instructions on how to apply it, when i applied it as instructed i was totally cured from the virus within 3 weeks of usage. Contact this great herbal doctor today to get your cure. 
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    ReplyDelete
  19. Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR agaba helped someone in curing his HERPES disease, quickly I copied his email which is Dragabasolutionhome@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on : Dragabasolutionhome@gmail.com or WhatApp: +2349074536486  

    ReplyDelete
  20. I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
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    treatment! This treatment is a breakthrough for all HBV carriers.

    ReplyDelete
  21. There is a great herbal man called Dr voodoo who can cure Hepatitis B virus and other deadly diseases with the use of natural herbs to cure Hepatitis B virus problems. He is from Africa and he is a great doctor and he can also cure you as well if you are have the problem And other deadly disease and here is email address voodoospelltemple66@gmail.com or Whatsapp +2348140120719 HERPES CURE,CANCER CURE,HIV/AIDS CURE,HPV CURE

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  22. I’d recommend using Dr. Utu Herbal Cure topically for instant pain and itch relief as well as accelerated healing of lesions and permanently stopping oral and genital herpes virus outbreaks. I have tried just about everything from acyclovir suppressive therapy to different natural oils, extracts, and other natural methods, some of which are EXTREMELY painful and exacerbate the problem (i.e. apple cider vinegar!). While vitamin E oil and suppressive therapy worked well for me, when I became pregnant I went back to trying to find a herbal treatment. I was trying vitamin E oil topically for a while but it was thin and difficult to use and only seemed to prevent further outbreaks rather than getting rid of it. I contacted Dr. Utu Herbal Cure through my friend. To my surprise, I could tell my outbreak was starting to heal within only a few hours! No more itching and pain! Dr. Utu Herbal Cure that I used was liquid herbs in bottles, so it was very easy to use. It simply whiffs, but it works so I don’t care! The best part of my testimony was that I successfully delivered a herpes-free beautiful daughter without further medications. Anyone who has tried Dr. Utu Herbal Cure knows just how quickly those treatments can add up. So give it a try! Anyone can reach Dr. Utu through
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    ReplyDelete